Improving fruit and vegetable intake attenuates the genetic association with long-term weight gain.

ABSTRACT:

Background

Whether changes in fruit and vegetable intake can modify the effect of genetic susceptibility to obesity on long-term changes in BMI and body weight are uncertain.

Objective

We analyzed the interactions of changes in total and specific fruit and vegetable intake with genetic susceptibility to obesity in relation to changes in BMI and body weight.

Methods

We calculated a genetic risk score on the basis of 77 BMI-associated loci to determine the genetic susceptibility to obesity, and examined the interactions of changes in total and specific fruit and vegetable intake with the genetic risk score on changes in BMI and body weight within five 4-y intervals over 20 y of follow-up in 8943 women from the Nurses' Health Study (NHS) and 5308 men from the Health Prof

SUBMITTER: Wang T 

PROVIDER: S-EPMC6736184 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature