Proteomics approach to identify serum biomarkers associated with the progression of diabetes in Korean patients with abdominal obesity.

ABSTRACT: Type 2 diabetes is a metabolic disease with a group of metabolic derangements and inflammatory reactants in the serum. Despite the substantial public health implications, markers of diabetes progression with abdominal obesity are still needed to facilitate early detection and treatment. In this study, we performed a proteomic approach to identify differential target proteins underlying diabetes progression in patients with abdominal obesity. Proteomic differences were investigated in the serum of controls and patients with prediabetes or diabetes with or without abdominal obesity by 2-DE combined with MALDI-TOF-MS. Proteomics data were validated by western blot analyses and major protein-protein interactions were assessed using a network analysis with String database. Among 245 matched pro

SUBMITTER: Kim SW 

PROVIDER: S-EPMC6736247 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature