High-quality Schistosoma haematobium genome achieved by single-molecule and long-range sequencing.

ABSTRACT:

Background

Schistosoma haematobium causes urogenital schistosomiasis, a neglected tropical disease affecting >100 million people worldwide. Chronic infection with this parasitic trematode can lead to urogenital conditions including female genital schistosomiasis and bladder cancer. At the molecular level, little is known about this blood fluke and the pathogenesis of the disease that it causes. To support molecular studies of this carcinogenic worm, we reported a draft genome for S. haematobium in 2012. Although a useful resource, its utility has been somewhat limited by its fragmentation.

Findings

Here, we systematically enhanced the draft genome of S. haematobium using a single-molecule and long-range DNA-sequencing approach. We achieved a major improvement in the accuracy

SUBMITTER: Stroehlein AJ 

PROVIDER: S-EPMC6736295 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature