Circuit-based interventions in the dentate gyrus rescue epilepsy-associated cognitive dysfunction.

ABSTRACT: Temporal lobe epilepsy is associated with significant structural pathology in the hippocampus. In the dentate gyrus, the summative effect of these pathologies is massive hyperexcitability in the granule cells, generating both increased seizure susceptibility and cognitive deficits. To date, therapeutic approaches have failed to improve the cognitive symptoms in fully developed, chronic epilepsy. As the dentate's principal signalling population, the granule cells' aggregate excitability has the potential to provide a mechanistically-independent downstream target. We examined whether normalizing epilepsy-associated granule cell hyperexcitability-without correcting the underlying structural circuit disruptions-would constitute an effective therapeutic approach for cognitive dysfunction. In th

SUBMITTER: Kahn JB 

PROVIDER: S-EPMC6736326 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature