Robust Estimation of Recent Effective Population Size from Number of Independent Origins in Soft Sweeps.

ABSTRACT: Estimating recent effective population size is of great importance in characterizing and predicting the evolution of natural populations. Methods based on nucleotide diversity may underestimate current day effective population sizes due to historical bottlenecks, whereas methods that reconstruct demographic history typically only detect long-term variations. However, soft selective sweeps, which leave a fingerprint of mutational history by recurrent mutations on independent haplotype backgrounds, holds promise of an estimate more representative of recent population history. Here, we present a simple and robust method of estimation based only on knowledge of the number of independent recurrent origins and the current frequency of the beneficial allele in a population sample, independent of

SUBMITTER: Khatri BS 

PROVIDER: S-EPMC6736332 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature