The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration.

ABSTRACT:

Purpose

AMD is the leading cause of irreversible blindness in older individuals in the Western world, and there are currently no therapies to halt disease progression. Studies suggest that the commonly prescribed antidiabetic drug, metformin, is associated with decreased risk of several ocular diseases, but no work has investigated the effect of metformin use on development of AMD. Thus, we aim to investigate whether metformin use is associated with decreased risk of developing AMD.

Methods

In this retrospective case-control study, we used medical records from patients older than 55 who have visited a University of Florida health clinic. Three controls were matched for every AMD case, defined by International Classification of Diseases, Ninth Revision code, based on the Char

SUBMITTER: Brown EE 

PROVIDER: S-EPMC6736343 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature