Using a Multi-Stage hESC Model to Characterize BDE-47 Toxicity During Neurogenesis.

ABSTRACT: Although the ramifications associated with polybrominated diphenyl ethers (PBDEs) exposures during human pregnancy have yet to be determined, increasing evidence in humans and animal models suggests that these compounds cause neurodevelopmental toxicity. Human embryonic stem cells (hESCs) models can be used to study the effects of environmental chemicals throughout the successive stages of neuronal development. Here, using a hESC differentiation model, we investigated the effects of common PBDE congeners (BDE-47 or -99) on the successive stages of early neuronal development. First, we determined the points of vulnerability to PBDEs across 4 stages of in vitro neural development by using assays to assess for cytotoxicity. Differentiated neural progenitors were identified to be more sensitiv

SUBMITTER: Chen H 

PROVIDER: S-EPMC6736394 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature