Human Papillomavirus Viral Load and Transmission in Young, Recently Formed Heterosexual Couples.

ABSTRACT:

Background

We studied the association between human papillomavirus (HPV) viral load (VL) and HPV concordance.

Methods

The HITCH cohort study included young, heterosexual, recently formed, sexually active couples. Questionnaires and genital samples were collected at 0 and 4 months. Samples were tested for HPV DNA by polymerase chain reaction (PCR; Linear Array). VLs of HPV6/11/16/18/31/42/51 were quantified using type-specific real-time PCR. Correlations between VL and type-specific HPV prevalence and incidence were evaluated using multilevel, mixed-effects linear/logistic regression models.

Results

We included 492 couples. VLs were higher in penile than vaginal samples. VL at subsequent visits correlated significantly within men (r, 0.373), within women (r, 0.193), an

SUBMITTER: Wissing MD 

PROVIDER: S-EPMC6736425 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature