Impact of first-line cancer treatment on the follicle quality in cryopreserved ovarian samples from girls and young women.

ABSTRACT:

Study question

Does first-line chemotherapy affect the quality of ovarian pre-antral follicles and stromal tissue in a population of young patients?

Summary answer

Exposure to first-line chemotherapy significantly impacts follicle viability, size of residual intact follicles, steroid secretion in culture and quality of the stromal compartment.

What is known already

First-line chemotherapy is considered to have a low gonadotoxic potential, and as such, does not represent an indication for fertility preservation. Studies investigating the effects of chemotherapy on the quality of ovarian tissue stored for fertility preservation in young patients are limited and the results sometimes contradictory.

Study design, size, duration

We conducted a retrospective cohort s

SUBMITTER: Pampanini V 

PROVIDER: S-EPMC6736429 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature