Dietary quality and the colonic mucosa-associated gut microbiome in humans.

ABSTRACT:

Background

Despite tremendous interest in modulating the microbiome to improve health, the association between diet and the colonic mucosa-associated gut microbiome in healthy individuals has not been examined.

Objective

To investigate the associations between Healthy Eating Index (HEI)-2005 and the colonic mucosa-associated microbiota.

Methods

In this cross-sectional observational study, we analyzed bacterial community composition and structure using 16S rRNA gene (V4 region) sequencing of 97 colonic mucosal biopsies obtained endoscopically from different colon segments of 34 polyp-free participants. Dietary consumption was ascertained using an FFQ. Differences in α- and β-diversity and taxonomic relative abundances between the higher and lower score of total HEI and

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6736447 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature