Persistent low body weight in humans is associated with higher mitochondrial activity in white adipose tissue.

ABSTRACT:

Background

Constitutional thinness (CT) is a state of low but stable body weight (BMI ≤18 kg/m2). CT subjects have normal-range hormonal profiles and food intake but exhibit resistance to weight gain despite living in the modern world's obesogenic environment.

Objective

The goal of this study is to identify molecular mechanisms underlying this protective phenotype against weight gain.

Methods

We conducted a clinical overfeeding study on 30 CT subjects and 30 controls (BMI 20-25 kg/m2) matched for age and sex. We performed clinical and integrative molecular and transcriptomic analyses on white adipose and muscle tissues.

Results

Our results demonstrate that adipocytes were markedly smaller in CT individuals (mean ± SEM: 2174 ± 142 μm 2) compared with controls (3

SUBMITTER: Ling Y 

PROVIDER: S-EPMC6736451 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature