Physiologically based kinetic modelling-facilitated reverse dosimetry to predict in vivo red blood cell acetylcholinesterase inhibition following exposure to chlorpyrifos in the Caucasian and Chinese population.

ABSTRACT: Organophosphates (OPs) have a long history of use as insecticides over the world. The aim of the present study was to investigate the interethnic differences in kinetics, biomarker formation and in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition of chlorpyrifos (CPF) in the Chinese and the Caucasian population. To this purpose, PBK models for CPF in both the Chinese and Caucasian population were developed, and used to study time- and dose-dependent interethnic variation in urinary biomarkers and to convert concentration-response curves for RBC AChE inhibition to in vivo dose-response curves in these two populations by reverse dosimetry. The results obtained revealed a marked interethnic difference in toxicokinetics of CPF, with lower urinary biomarker levels at similar dos

SUBMITTER: Zhao S 

PROVIDER: S-EPMC6736452 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature