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Phenotypic and Ig Repertoire Analyses Indicate a Common Origin of IgD^-CD27^- Double Negative B Cells in Healthy Individuals and Multiple Sclerosis Patients.

ABSTRACT: IgD^-CD27^- double negative (DN) B cells with proinflammatory characteristics are abnormally elevated in a proportion of multiple sclerosis (MS) patients. In this study, the origin and selection characteristics of DN B cells were studied in MS patients and healthy controls (HC). Expression of developmental markers on peripheral blood DN, IgD^-CD27⁺ class-switched memory (CSM) and IgD⁺CD27^- naive B cells of HC (n = 48) and MS patients (n = 96) was determined by flow cytometry. High-throughput adaptive immune receptor repertoire sequencing was performed on peripheral blood DN and CSM B cells of HC and MS patients (n = 3 each). DN B cells from HC and MS patients showed similar phenotypic and Ig repertoire char

SUBMITTER: Fraussen J

PROVIDER: S-EPMC6736705 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Dataset Information

Phenotypic and Ig Repertoire Analyses Indicate a Common Origin of IgD^-CD27^- Double Negative B Cells in Healthy Individuals and Multiple Sclerosis Patients.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Phenotypic and Ig Repertoire Analyses Indicate a Common Origin of IgD-CD27- Double Negative B Cells in Healthy Individuals and Multiple Sclerosis Patients.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Phenotypic and Ig Repertoire Analyses Indicate a Common Origin of IgD^-CD27^- Double Negative B Cells in Healthy Individuals and Multiple Sclerosis Patients.