Association between First Trimester Antidepressant Use and Risk of Spontaneous Abortion.

ABSTRACT:

Study objective

The potential for maternal antidepressant use to influence the risk of spontaneous abortion, one of the most important adverse pregnancy outcomes, is not clear. We aimed to assess whether first trimester antidepressant exposure was associated with an increased risk of spontaneous abortion.

Design

Community-based prospective cohort study (Right from the Start).

Setting

Eight metropolitan areas in North Carolina, Tennessee, and Texas.

Participants

A total of 5451 women (18 years of age or older) who were planning to conceive or were pregnant (before 12 weeks of completed gestation) and were enrolled in the study between 2000 and 2012; of those women, 223 used antidepressants (selective serotonin reuptake inhibitors [SSRIs] only [170], SSRIs and no

SUBMITTER: Wu P 

PROVIDER: S-EPMC6736709 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature