Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients.

ABSTRACT: Alterations in the gene expression of organs in contact with the environment may signal exposure to toxins. To identify genes in lung tissue whose expression levels are altered by cigarette smoking, we compared the transcriptomes of lung tissue between 118 ever smokers and 58 never smokers. In all cases, the tissue studied was non-involved lung tissue obtained at lobectomy from patients with lung adenocarcinoma. Of the 17,097 genes analyzed, 357 were differentially expressed between ever smokers and never smokers (FDR < 0.05), including 290 genes that were up-regulated and 67 down-regulated in ever smokers. For 85 genes, the absolute value of the fold change was ≥2. The gene with the smallest FDR was MYO1A (FDR = 6.9 × 10^-4) while the gene with the largest difference between gro

SUBMITTER: Pintarelli G 

PROVIDER: S-EPMC6736939 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature