Dynamics of centriole amplification in centrosome-depleted brain multiciliated progenitors.

ABSTRACT: Reproductive and respiratory organs, along with brain ventricles, are lined by multiciliated epithelial cells (MCC) that generate cilia-powered fluid flows. MCC hijack the centrosome duplication pathway to form hundreds of centrioles and nucleate motile cilia. In these cells, the large majority of procentrioles are formed associated with partially characterized organelles called deuterosomes. We recently challenged the paradigm that deuterosomes and procentrioles are formed de novo by providing data, in brain MCC, suggesting that they are nucleated from the pre-existing centrosomal younger centriole. However, the origin of deuterosomes and procentrioles is still under debate. Here, we further question centrosome importance for deuterosome and centriole amplification. First, we provide addi

SUBMITTER: Mercey O 

PROVIDER: S-EPMC6736942 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature