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Non-invasive Potential Circulating mRNA Markers for Colorectal Adenoma Using Targeted Sequencing.

ABSTRACT: We have developed an optimized protocol for plasma targeted mRNA sequencing in our previous study. Here, we performed plasma targeted mRNA sequencing for 40 colorectal adenoma patients and 39 colonoscopy-proven normal controls in order to find potential circulating mRNA markers for colorectal adenoma. Results showed that GSK3A and RHOA were differential expressed genes identified by a cut-off of fold change >2 and adjusted P value?

SUBMITTER: Xue VW 

PROVIDER: S-EPMC6736954 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Non-invasive Potential Circulating mRNA Markers for Colorectal Adenoma Using Targeted Sequencing.

Xue Vivian W VW   Cheung Moon T MT   Chan Pak T PT   Luk Lewis L Y LLY   Lee Vivian H VH   Au Thomas C TC   Yu Allen C AC   Cho William C S WCS   Tsang Hin Fung Andy HFA   Chan Amanda K AK   Wong S C Cesar SCC  

Scientific reports 20190910 1

We have developed an optimized protocol for plasma targeted mRNA sequencing in our previous study. Here, we performed plasma targeted mRNA sequencing for 40 colorectal adenoma patients and 39 colonoscopy-proven normal controls in order to find potential circulating mRNA markers for colorectal adenoma. Results showed that GSK3A and RHOA were differential expressed genes identified by a cut-off of fold change >2 and adjusted P value < 0.05. More detailed analysis showed that the expression of both  ...[more]

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