Promyelocytic Leukemia (PML) gene regulation: implication towards curbing oncogenesis.

ABSTRACT: Dysregulation of PML, a significant tumor suppressor is linked with cancers of different histological origins, with a decreased expression observed with a higher tumor grade. This necessitates studying the mechanisms to maintain a stable expression of PML. However much less is known about the transcriptional regulation of PML, more so in the context of breast carcinoma. ERβ has emerged as a critical factor in understanding breast cancer, especially since a huge proportion of breast cancers are ERα^- and thus insensitive to tamoxifen therapy. This study aims to uncover an unidentified mechanism of PML gene regulation and its stabilization in breast cancer via ERβ signalling and the impact on cellular apoptosis. We found that clinical expression of PML positively correlates with th

SUBMITTER: Datta N 

PROVIDER: S-EPMC6736969 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature