Plasmacytoid DCs From Patients With Sjogren's Syndrome Are Transcriptionally Primed for Enhanced Pro-inflammatory Cytokine Production.

ABSTRACT: Primary Sjögren's syndrome (pSS) is a systemic auto-immune disease typified by dryness of the mouth and eyes. A majority of patients with pSS have a type-I interferon (IFN)-signature, which is defined as the increased expression of IFN-induced genes in circulating immune cells and is associated with increased disease activity. As plasmacytoid dendritic cells (pDC) are the premier type-I IFN-producing cells and are present at the site of inflammation, they are thought to play a significant role in pSS pathogenesis. Considering the lack of data on pDC regulation and function in pSS patients, we here provided the first in-depth molecular characterization of pSS pDCs. In addition, a group of patients with non-Sjögren's sicca (nSS) was included; these poorly studied patients suffer from complai

SUBMITTER: Hillen MR 

PROVIDER: S-EPMC6736989 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature