Listeria monocytogenes σ^A Is Sufficient to Survive Gallbladder Bile Exposure.

ABSTRACT: Listeria monocytogenes is a foodborne Gram-positive bacterium causing listeriosis in both animals and humans. It can persist and grow in various environments including conditions countered during saprophytic or intra-host lifestyles. Sigma (σ) subunit of RNA polymerase is a transcriptional factor responsible for guiding the core RNA polymerase and initiating gene expression under normal growth or physiological changes. In L. monocytogenes, there is one housekeeping sigma factor, σ^A, and four alternative sigma factors σ^B, σ^C, σ^H, and σ^L. Generally, σ^A directs expression of genes required for normal growth while alternative σ factors alter gene expression in response to specific conditions (e.g., stress). In this

SUBMITTER: Boonmee A 

PROVIDER: S-EPMC6737072 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature