Memory Decline and Behavioral Inflexibility in Aged Mice Are Correlated With Dysregulation of Protein Synthesis Capacity.

ABSTRACT: Understanding the molecular mechanisms underlying age-associated cognitive impairments will not only contribute to our general knowledge about "aging" biology, but also provide insights for more effective strategies to prevent and improve the quality of life for both normal aging and pathological aging such as Alzheimer's disease (AD). Here we first assessed and compared the performance of cognition and synaptic plasticity in young (3-5-month old) and aged c57BL/6J mice (19-21 months old). Findings from behavioral tests demonstrated that old mice, compared to young mice, displayed impairments in spatial learning/memory, working memory, and behavioral flexibility. Further, synaptic electrophysiology experiments on hippocampal slices revealed that the early form of long-term potentiation (LT

SUBMITTER: Yang W 

PROVIDER: S-EPMC6737270 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature