Crosstalk network among multiple inflammatory mediators in liver fibrosis.

ABSTRACT: Liver fibrosis is the common pathological basis of all chronic liver diseases, and is the necessary stage for the progression of chronic liver disease to cirrhosis. As one of pathogenic factors, inflammation plays a predominant role in liver fibrosis via communication and interaction between inflammatory cells, cytokines, and the related signaling pathways. Damaged hepatocytes induce an increase in pro-inflammatory factors, thereby inducing the development of inflammation. In addition, it has been reported that inflammatory response related signaling pathway is the main signal transduction pathway for the development of liver fibrosis. The crosstalk regulatory network leads to hepatic stellate cell activation and proinflammatory cytokine production, which in turn initiate the fibrot

SUBMITTER: Zhangdi HJ 

PROVIDER: S-EPMC6737310 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature