The Challenges of Chromosome Y Analysis and the Implications for Chronic Kidney Disease.

ABSTRACT: The role of chromosome Y in chronic kidney disease (CKD) remains unknown, as chromosome Y is typically excluded from genetic analysis in CKD. The complex, sex-specific presentation of CKD could be influenced by chromosome Y genetic variation, but there is limited published research available to confirm or reject this hypothesis. Although traditionally thought to be associated with male-specific disease, evidence linking chromosome Y genetic variation to common complex disorders highlights a potential gap in CKD research. Chromosome Y variation has been associated with cardiovascular disease, a condition closely linked to CKD and one with a very similar sexual dimorphism. Relatively few sources of genetic variation in chromosome Y have been examined in CKD. The association between chromosom

SUBMITTER: Anderson K 

PROVIDER: S-EPMC6737325 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature