Blame-rebalance fMRI neurofeedback in major depressive disorder: A randomised proof-of-concept trial.

ABSTRACT: Previously, using fMRI, we demonstrated lower connectivity between right anterior superior temporal (ATL) and anterior subgenual cingulate (SCC) regions while patients with major depressive disorder (MDD) experience guilt. This neural signature was detected despite symptomatic remission which suggested a putative role in vulnerability. This randomised controlled double-blind parallel group clinical trial investigated whether patients with MDD are able to voluntarily modulate this neural signature. To this end, we developed a fMRI neurofeedback software (FRIEND), which measures ATL-SCC coupling and displays its levels in real time. Twenty-eight patients with remitted MDD were randomised to two groups, each receiving one session of fMRI neurofeedback whilst retrieving guilt and indignation/a

SUBMITTER: Zahn R 

PROVIDER: S-EPMC6737344 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature