Vaccine safety studies of Brucella abortus S19 and S19ΔvjbR in pregnant swine.

ABSTRACT: Brucellosis in swine is caused by Brucella suis, a bacterial infection of nearly worldwide distribution. Brucella suis is also transmissible to humans, dogs and cattle and is considered a reemerging disease of public health concern. To date, there is no effective vaccine for swine. This prompted us to investigate the potential use of the commercially available vaccine for cattle or the live attenuated vaccine candidate S19ΔvjbR. As the first step, we sought to study the safety of the vaccine candidates when administered in pregnant sows, since one of the major drawbacks associated with vaccination using Live Attenuated Vaccines (LAV) is the induction of abortions when administered in pregnant animals. Fifteen pregnant gilts at mid-gestation were divided into four group

SUBMITTER: Zriba S 

PROVIDER: S-EPMC6737346 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature