Mathematical modelling of trastuzumab-induced immune response in an in vivo murine model of HER2+ breast cancer.

ABSTRACT: The goal of this study is to develop an integrated, mathematical-experimental approach for understanding the interactions between the immune system and the effects of trastuzumab on breast cancer that overexpresses the human epidermal growth factor receptor 2 (HER2+). A system of coupled, ordinary differential equations was constructed to describe the temporal changes in tumour growth, along with intratumoural changes in the immune response, vascularity, necrosis and hypoxia. The mathematical model is calibrated with serially acquired experimental data of tumour volume, vascularity, necrosis and hypoxia obtained from either imaging or histology from a murine model of HER2+ breast cancer. Sensitivity analysis shows that model components are sensitive for 12 of 13 parameters, but accounting

SUBMITTER: Jarrett AM 

PROVIDER: S-EPMC6737347 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature