Reticulocyte and red blood cell deformation triggers specific phosphorylation events.

ABSTRACT: The capacity to undergo substantial deformation is a defining characteristic of the red blood cell (RBC), facilitating transit through the splenic interendothelial slits and microvasculature. Establishment of this remarkable property occurs during a process of reticulocyte maturation that begins with egress through micron-wide pores in the bone marrow and is completed within the circulation. The requirement to undertake repeated cycles of deformation necessitates that both reticulocytes and erythrocytes regulate membrane-cytoskeletal protein interactions in order to maintain cellular stability. In the absence of transcriptional activity, modulation of these interactions in RBCs is likely to be achieved primarily through specific protein posttranslational modifications, which at present rem

SUBMITTER: Moura PL 

PROVIDER: S-EPMC6737423 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature