Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial.

ABSTRACT:

Objective

To assess the effects of Helicobacter pylori treatment, vitamin supplementation, and garlic supplementation in the prevention of gastric cancer.

Design

Blinded randomized placebo controlled trial.

Setting

Linqu County, Shandong province, China.

Participants

3365 residents of a high risk region for gastric cancer. 2258 participants seropositive for antibodies to H pylori were randomly assigned to H pylori treatment, vitamin supplementation, garlic supplementation, or their placebos in a 2×2×2 factorial design, and 1107 H pylori seronegative participants were randomly assigned to vitamin supplementation, garlic supplementation, or their placebos in a 2×2 factorial design.

Interventions

H pylori treatment with am

SUBMITTER: Li WQ 

PROVIDER: S-EPMC6737461 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature