Schizophrenia is Associated With an Aberrant Immune Response to Epstein-Barr Virus.

ABSTRACT:

Background

Epstein-Barr virus (EBV) is a highly prevalent human herpesvirus capable of infecting the central nervous system and establishing persistent infection.

Methods

We employed solid phase immunoassay techniques to measure immunoglobulin G (IgG) class antibodies to EBV virions and defined proteins in 432 individuals with schizophrenia and 311 individuals without a history of a psychiatric disorder. Western blot testing was performed to document reactivity to specific EBV proteins. Polygenic risk for schizophrenia was calculated from genome sequencing arrays. Levels of antibodies between the groups were compared by multivariate analyses incorporating clinical, genetic, and demographic measures.

Results

Individuals with schizophrenia had marked elevations in the l

SUBMITTER: Dickerson F 

PROVIDER: S-EPMC6737467 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature