Genetic Variation in the Psychiatric Risk Gene CACNA1C Modulates Reversal Learning Across Species.

ABSTRACT: Genetic variation in CACNA1C, which encodes the alpha-1 subunit of Cav1.2 L-type voltage-gated calcium channels (VGCCs), has been strongly linked to risk for psychiatric disorders including schizophrenia and bipolar disorder. How genetic variation in CACNA1C contributes to risk for these disorders is however not fully known. Both schizophrenia and bipolar disorder are associated with impairments in reversal learning (RL), which may contribute to symptoms seen in these conditions. We used a translational RL paradigm to investigate whether genetic variation in CACNA1C affects RL in both humans and transgenic rats. Associated changes in gene expression were explored using in situ hybridization and quantitative PCR in rats and the BRAINEAC online human database. Risk-associated genetic variati

SUBMITTER: Sykes L 

PROVIDER: S-EPMC6737471 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature