Controlling Synchronization of Spiking Neuronal Networks by Harnessing Synaptic Plasticity.

ABSTRACT: Disrupting the pathological synchronous firing patterns of neurons with high frequency stimulation is a common treatment for Parkinsonian symptoms and epileptic seizures when pharmaceutical drugs fail. In this paper, our goal is to design a desynchronization strategy for large networks of spiking neurons such that the neuronal activity of the network remains in the desynchronized regime for a long period of time after the removal of the stimulation. We develop a novel "Forced Temporal-Spike Time Stimulation (FTSTS)" strategy that harnesses the spike-timing dependent plasticity to control the synchronization of neural activity in the network by forcing the neurons in the network to artificially fire in a specific temporal pattern. Our strategy modulates the synaptic strengths of selective s

SUBMITTER: Schmalz J 

PROVIDER: S-EPMC6737503 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature