Structural brain characteristics in treatment-resistant depression: review of magnetic resonance imaging studies.

ABSTRACT:

Background

Major depressive disorder (MDD) has been related to structural brain characteristics that are correlated with the severity of disease. However, the correlation of these structural changes is less well clarified in treatment-resistant depression (TRD).

Aims

To summarise the existing literature on structural brain characteristics in TRD to create an overview of known abnormalities of the brain in patients with MDD, to form hypotheses about the absence or existence of a common pathophysiology of MDD and TRD.

Method

A systematic search of PubMed and the Cochrane Library for studies published between 1998 and August of 2016 investigating structural brain changes in patients with TRD compared with healthy controls or patients with MDD.

Results

Fourteen art

SUBMITTER: Klok MPC 

PROVIDER: S-EPMC6737518 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature