Gastrointestinal microbiota alteration induced by Mucor circinelloides in a murine model.

ABSTRACT: Mucor circinelloides is a pathogenic fungus and etiologic agent of mucormycosis. In 2013, cases of gastrointestinal illness after yogurt consumption were reported to the US FDA, and the producer found that its products were contaminated with Mucor. A previous study found that the Mucor strain isolated from an open contaminated yogurt exhibited virulence in a murine systemic infection model and showed that this strain is capable of surviving passage through the gastrointestinal tract of mice. In this study, we isolated another Mucor strain from an unopened yogurt that is closely related but distinct from the first Mucor strain and subsequently examined if Mucor alters the gut microbiota in a murine host model. DNA extracted from a ten-day course of stool samples was used to analyze the micr

SUBMITTER: Mueller KD 

PROVIDER: S-EPMC6737537 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature