Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling.

ABSTRACT: The first total synthesis and structural validation of phosdiecin A was accomplished in 13 steps through asymmetric iridium-catalyzed alcohol-mediated carbonyl reductive coupling. The present route is the shortest among >30 total and formal syntheses of fostriecin family members.

SUBMITTER: Della-Felice F 

PROVIDER: S-EPMC6737538 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature