Genome-wide effects of social status on DNA methylation in the brain of a cichlid fish, Astatotilapia burtoni.

ABSTRACT:

Background

Successful social behavior requires real-time integration of information about the environment, internal physiology, and past experience. The molecular substrates of this integration are poorly understood, but likely modulate neural plasticity and gene regulation. In the cichlid fish species Astatotilapia burtoni, male social status can shift rapidly depending on the environment, causing fast behavioral modifications and a cascade of changes in gene transcription, the brain, and the reproductive system. These changes can be permanent but are also reversible, implying the involvement of a robust but flexible mechanism that regulates plasticity based on internal and external conditions. One candidate mechanism is DNA methylation, which has been linked to social behavior in

SUBMITTER: Hilliard AT 

PROVIDER: S-EPMC6737626 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature