Prepulse inhibition in patients with bipolar disorder: a systematic review and meta-analysis.

ABSTRACT:

Background

Prepulse inhibition (PPI) is a measurement method for the sensory gating process, which helps the brain adapt to complex environments. PPI may be reduced in patients with bipolar disorder (BD). This study investigated PPI deficits in BD and pooled the effect size of PPI in patients with BD.

Methods

We conducted a literature search on PPI in patients with BD from inception to July 27, 2019 in PubMed, Embase, Cochrane Library databases, and Chinese databases. No age, sex, and language restriction were set. The calculation formula was PPI = 100 - [100*((prepulse - pulse amplitude) / pulse amplitude)]. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of studies.

Results

Ten eligible papers were identified, of which five studies including a total

SUBMITTER: Mao Z 

PROVIDER: S-EPMC6737635 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature