Possible beneficial association between renin-angiotensin-aldosterone-system blockade usage and graft prognosis in allograft IgA nephropathy: a retrospective cohort study.

ABSTRACT:

Background

Although immunoglobulin A nephropathy (IgAN) is associated with an increased risk of renal allograft failure, evidences for its treatment, including renin-angiotensin-aldosterone system blockade (RAASB) usage, remain limited.

Methods

In this bi-center retrospective cohort study, we included patients who were recently diagnosed with IgAN through allograft biopsies. We identified their 6-month antihypertensive medication prescriptions and investigated the association between the medication types, albuminuria changes, and risk of 5-year death-censored-graft-failure (DCGF). The mixed effect model and cox regression analysis were used.

Results

A total of 464 allograft IgAN patients were included: 272, 38, 33, and 121 patients in the no antihypertensive medicatio

SUBMITTER: Park S 

PROVIDER: S-EPMC6737644 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature