White matter abnormalities of corpus callosum in patients with bipolar disorder and suicidal ideation.

ABSTRACT:

Objective

Although many studies have shown that the corpus callosum (CC) may play an important role in bipolar disorder (BD) and suicide, the pathophysiological mechanism of BD underlying suicidal behavior is still unclear. This study aimed to explore the relationship between the CC, and BD and suicidal ideation using diffusion tensor imaging (DTI).

Method

A total of 203 participants (47 BD patients with suicidal ideation, 59 with BD without suicidal ideation, and 97 healthy controls [HC]) underwent DTI scanning at a single site. We examined the white matter integrity of the CC in the three groups.

Results

A comparison among groups showed that BD patients with suicidal ideation had significant lower fractional anisotropy (FA) values than those of BD without suicidal i

SUBMITTER: Zhang R 

PROVIDER: S-EPMC6737682 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature