Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis.

ABSTRACT:

Background

Osteoarthritis has been associated with a plethora of pathological factors and one which has recently emerged is chondrocyte endoplasmic reticulum (ER) stress. ER stress is sensed by key ER-resident stress sensors, one of which is activating transcription factor 6 (ATF6). The purpose of this study is to determine whether increased ER stress plays a role in OA.

Methods

OA was induced in male wild-type (+/+), ColIITg^cog (c/c) and Atf6α^-/- mice by destabilisation of the medial meniscus (DMM). c/c mice have increased ER stress in chondrocytes via the collagen II promoter-driven expression of ER stress-inducing Tg^cog. Knee joints were scored histologically for OA severity. RNA-seq was performed on laser-micro-dissected RNA from cartilag

SUBMITTER: Kung LHW 

PROVIDER: S-EPMC6737683 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature