The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance.

ABSTRACT:

Background

Radiotherapy (RT) is a highly effective multimodal nonsurgical treatment that is essential for patients with advanced colorectal cancer (CRC). Nevertheless, cell subpopulations displaying intrinsic radioresistance survive after RT. The reactivation of their proliferation and successful colonization at local or distant sites may increase the risk of poor clinical outcomes. Recently, radioresistant cancer cells surviving RT were reported to exhibit a more aggressive phenotype than parental cells, although the underlying mechanisms remain unclear.

Methods

By investigating public databases containing CRC patient data, we explored potential radioresistance-associated signaling pathways. Then, their mechanistic roles in radioresistance were investigated through multiple

SUBMITTER: Park SY 

PROVIDER: S-EPMC6737692 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature