Estrogen receptors promote NSCLC progression by modulating the membrane receptor signaling network: a systems biology perspective.

ABSTRACT:

Background

Estrogen receptors (ERs) are thought to play an important role in non-small cell lung cancer (NSCLC). However, the effect of ERs in NSCLC is still controversial and needs further investigation. A new consideration is that ERs may affect NSCLC progression through complicated molecular signaling networks rather than individual targets. Therefore, this study aims to explore the effect of ERs in NSCLC from the perspective of cancer systems biology.

Methods

The gene expression profile of NSCLC samples in TCGA dataset was analyzed by bioinformatics method. Variations of cell behaviors and protein expression were detected in vitro. The kinetic process of molecular signaling network was illustrated by a systemic computational model. At last, immunohistochemical (IHC) and

SUBMITTER: Gao X 

PROVIDER: S-EPMC6737693 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature