Serum metabolomic alterations in Beagle dogs experimentally infected with Toxocara canis.

ABSTRACT:

Background

Toxocara canis, a globally distributed roundworm, can cause debilitating disease in dogs and humans; however, little is known about the metabolomic response of the hosts to T. canis infection. There is an increasing need to understand the metabolic mechanisms underlying the pathogenesis of T. canis infection in dogs. Here, we examined the metabolomic changes in Beagle dogs' serum following T. canis infection using LC-MS/MS.

Results

The metabolic profiles of Beagle dogs' serum were determined at 12 h, 24 h, 10 d and 36 d after oral infection with 300 infectious T. canis eggs by LC-MS/MS. We tested whether the T. canis-associated differentially abundant metabolites could distinguish the serum of infected dogs from controls, as measured by the area under the receiver

SUBMITTER: Zheng WB 

PROVIDER: S-EPMC6737696 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature