Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis.

ABSTRACT:

Background

Prodynorphin (PDYN) gene polymorphisms have been linked with opioid dependence (OD) with conflicting outcomes, the aim of this study is to synthesize the existing evidence of the association between PDYN polymorphisms and OD susceptibility.

Methods

Four databases including PubMed, EMBASE, Web of Science, and Wanfang were retrieved for relevant studies before August, 2018. All identified studies were evaluated using predetermined inclusion and exclusion criteria. Summary odds ratio (OR) and 95% confidence interval (95%CI) were calculated to appraise the association. Statistical analysis was performed using RevMan 5.3 software.

Results

A total of seven case-control studies with 3129 cases and 3289 controls were recruited in the meta-analysis. For rs910080, rs

SUBMITTER: Wang CW 

PROVIDER: S-EPMC6737717 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature