Night shift work and risk of breast cancer in women: the Generations Study cohort.

ABSTRACT:

Background

It is plausible that night shift work could affect breast cancer risk, possibly by melatonin suppression or circadian clock disruption, but epidemiological evidence is inconclusive.

Methods

Using serial questionnaires from the Generations Study cohort, we estimated hazard ratios (HR) and 95% confidence intervals (95%CI) for breast cancer in relation to being a night shift worker within the last 10 years, adjusted for potential confounders.

Results

Among 102,869 women recruited in 2003-2014, median follow-up 9.5 years, 2059 developed invasive breast cancer. The HR in relation to night shift work was 1.00 (95%CI: 0.86-1.15). There was a significant trend with average hours of night work per week (P = 0.035), but no significantly raised risks for hours worked

SUBMITTER: Jones ME 

PROVIDER: S-EPMC6738051 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature