Dataset Information

Poor outcome in hypoxic endometrial carcinoma is related to vascular density.

ABSTRACT:

Background

Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients.

Methods

Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). CAIX expression was determined in epithelial tumour cells, with a cut-off of 1%. MVD was assessed according to the Weidner method. Correlations with disease-specific survival (DSS), disease-free survival (DFS) and distant disease-free survival (DDFS) were calculated using Kaplan-Meier curves and Cox regression analysis.

Results

Sixty-three (16.4%) of 385 ECs showed positive CAIX expression with high vascular density. These ECs had a reduced DSS compared to tumours with either hypoxia or high vascular density (log-rank p = 0.002). Multivariable analysis showed that hypoxic tumours with high vascular density had a reduced DSS (hazard ratio [HR] 3.71, p = 0.002), DDFS (HR 2.68, p = 0.009) and a trend for reduced DFS (HR 1.87, p = 0.054).

Conclusions

This study has shown that adverse outcome in hypoxic ECs is seen in the presence of high vascular density, suggesting an important role of angiogenesis in the metastatic process of hypoxic EC. Differential adjuvant treatment might be indicated for these patients.

SUBMITTER: Reijnen C

PROVIDER: S-EPMC6738053 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Publications

Poor outcome in hypoxic endometrial carcinoma is related to vascular density.

Reijnen Casper C van Weelden Willem Jan WJ Arts Martijn S J P MSJP Peters Johan P JP Rijken Paul F PF van de Vijver Koen K Santacana Maria M Bronsert Peter P Bulten Johan J Hirschfeld Marc M Colas Eva E Gil-Moreno Antonio A Reques Armando A Mancebo Gemma G Krakstad Camilla C Trovik Jone J Haldorsen Ingfrid S IS Huvila Jutta J Koskas Martin M Weinberger Vit V Minar Lubos L Jandakova Eva E Snijders Marc P L M MPLM van den Berg-van Erp Saskia S Küsters-Vandevelde Heidi V N HVN Matias-Guiu Xavier X Amant Frederic F Massuger Leon F A G LFAG Bussink Johan J Pijnenborg Johanna M A JMA

British journal of cancer 20190423 11

<h4>Background</h4>Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients.<h4>Methods</h4>Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). CAIX expression was determined in epithelial tumour cells, with a cut-off of 1%. MVD was assessed accordin ...[more]

PMID: 31011231

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Dataset Information

Poor outcome in hypoxic endometrial carcinoma is related to vascular density.

Background

Methods

Results

Conclusions

Publications

Poor outcome in hypoxic endometrial carcinoma is related to vascular density.

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