Tumour-infiltrating CD8⁺ lymphocytes and colorectal cancer recurrence by tumour and nodal stage.

ABSTRACT:

Background

Intratumoural T-cell infiltrate intensity cortes wrelaith clinical outcome in stage II/III colorectal cancer (CRC). We aimed to determine whether this association varies across this heterogeneous group.

Methods

We performed a pooled analysis of 1804 CRCs from the QUASAR2 and VICTOR trials. Intratumoural CD8⁺ and CD3⁺ densities were quantified by immunohistochemistry in tissue microarray (TMA) cores, and their association with clinical outcome analysed by Cox regression. We validated our results using publicly available gene expression data in a pooled analysis of 1375 CRCs from seven independent series.

Results

In QUASAR2, intratumoural CD8⁺ was a stronger predictor of CRC recurrence than CD3⁺ and showed similar d

SUBMITTER: Glaire MA 

PROVIDER: S-EPMC6738075 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature