Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer.

ABSTRACT:

Background

Identification of biomarkers associated with benefit of adjuvant chemotherapy in stage II/III colon cancer is an important task.

Methods

Vessel density (VD) and tumour stroma were analysed in a randomised-trial-derived discovery cohort (n = 312) and in a stage II/III group of a population-based validation cohort (n = 85). VD was scored separately in the tumour centre, invasive margin and peritumoral stroma compartments and quantitated as VD/total analysed tissue area or VD/stroma area.

Results

High stroma-normalised VD in the invasive margin was associated with significantly longer time to recurrence and overall survival (OS) (p = 0.002 and p = 0.006, respectively) in adjuvant-treated patients of the discovery cohort, but not in surgery-only patients. Strom

SUBMITTER: Mezheyeuski A 

PROVIDER: S-EPMC6738077 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature