Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes.

ABSTRACT:

Background

Previous studies suggested that the metabolism is differently reprogrammed in the major subtypes of non-small cell lung cancer (NSCLC), squamous cell carcinomas (SCC) and adenocarcinomas (AdC). However, a comprehensive analysis of this differential metabolic reprogramming is lacking.

Methods

Publicly available gene expression data from human lung cancer samples and cell lines were analysed. Stable isotope resolved metabolomics were performed on SCC and ADC tumours in human patients and in freshly resected tumour slices.

Results

Analysis of multiple transcriptomics data from human samples identified a SCC-distinguishing enzyme gene signature. SCC tumours from patients infused with [U-¹³C]-glucose and SCC tissue slices incubated with stable isotope

SUBMITTER: Sellers K 

PROVIDER: S-EPMC6738087 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature