A key genomic subtype associated with lymphovascular invasion in invasive breast cancer.

ABSTRACT:

Background

Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, remain unclear. This study, using available large transcriptomic datasets, aims to identify genes associated with LVI in early-stage BC patients.

Methods

Gene expression data from the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohort (n = 1565) was used as a discovery dataset, and The Cancer Genome Atlas (TCGA; n = 854) cohort was used as a validation dataset. Key genes were identified on the basis of differential mRNA expression with respect to LVI status as characterised by histological review. The relationships among LVI-associate

SUBMITTER: Kurozumi S 

PROVIDER: S-EPMC6738092 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature