High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer.

ABSTRACT:

Background

Microsatellite-unstable (MSI) tumours show a high load of mutational neoantigens, as a consequence of DNA mismatch repair deficiency. Consequently, MSI tumours commonly present with dense immune infiltration and develop immune evasion mechanisms. Whether improved lymphocyte recruitment contributes to the pronounced immune infiltration in MSI tumours is unknown. We analysed the density of high endothelial venules (HEV) and postcapillary blood vessels specialised for lymphocyte trafficking, in MSI colorectal cancers (CRC).

Methods

HEV density was determined by immunohistochemical staining of FFPE tissue sections from MSI (n = 48) and microsatellite-stable (MSS, n = 35) CRCs. Associations with clinical and pathological variables were analysed.

Results

We found

SUBMITTER: Pfuderer PL 

PROVIDER: S-EPMC6738093 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature